Matthias Gröschel

Resident physician internal medicine @ Charité - Universitätsmedizin Berlin

Contact me: matthias [dot] groeschel [at] charite [dot] de

More info and social media: CV, Bluesky, Github

I am a resident physician in internal medicine and junior group leader at Charité - Universitätsmedizin Berlin. My group's research interest centers around the use of next generation sequencing and epidemiological data to improve our understanding of Mycobacterium tuberculosis transmission. We develop and test the applicability of large language models in clinical medicine. Previously, I was a research fellow at the Department of Biomedical Informatics at Harvard Medical School. Before that, I graduated with an MD-PhD from the University of Groningen, The Netherlands. My doctoral research took place at the Institut Pasteur Paris where I generated BCG mutants including ESX-1 secretion systems to improve on BCG vaccine efficacy. Please reach out if you are interested in working with us.

Molecular epidemiology and drug resistance of pathogens

• Matthias I Gröschel, Pérez-Llanos FJ, Diel R, Vargas R Jr, Escuyer V, Musser K, Trieu L, Meissner JS, Knorr J, Klinkenberg D, Kouw P, Homolka S, Samek W, Mathema B, van Soolingen D, Niemann S, Ahuja SD, Farhat MR. “Differential rates of Mycobacterium tuberculosis transmission associate with host–pathogen sympatry” Nature Microbiology 2024.
• Matthias I Gröschel, Martin Owens, Luca Freschi, Roger Vargas Jr, Maximilian G Marin, Jody Phelan, Zamin Iqbal, Avika Dixit, Maha R Farhat. “GenTB: A user-friendly genome-based predictor for tuberculosis resistance powered by machine learning” Genome Medicine 2021.
• Matthias I Gröschel, Conor J Meehan, Ivan Barilar, Margo Diricks, Aitor Gonzaga, Matthias Steglich, Oscar Conchillo-Solé, Isabell-Christin Scherer, Uwe Mamat, Christian F Luz, Katrien De Bruyne, Christian Utpatel, Daniel Yero, Isidre Gibert, Xavier Daura, Stefanie Kampmeier, Nurdyana Abdul Rahman, Michael Kresken, Tjip S van der Werf, Ifey Alio, Wolfgang R Streit, Kai Zhou, Thomas Schwartz, John WA Rossen, Maha R Farhat, Ulrich E Schaible, Ulrich Nübel, Jan Rupp, Joerg Steinmann, Stefan Niemann, Thomas A Kohl. “The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia ” Nature Communications 2020.
• Sönke Andres*, Matthias I Gröschel*, Doris Hillemann, Matthias Merker, Stefan Niemann, Katharina Kranzer. “A diagnostic algorithm to investigate pyrazinamide and ethambutol resistance in rifampin-resistant Mycobacterium tuberculosis isolates in a low-incidence setting” Antimicrobial Agents and Chemotherapy 2019. *shared first authors
• Matthias I Gröschel, Timothy M Walker, Tjip S van der Werf, Christoph Lange, Stefan Niemann, Matthias Merker. “Pathogen-based precision medicine for drug-resistant tuberculosis” PloS Pathogens 2018.

Artificial Intelligence

• Andrew Farlow, Alexander Hoffmann, Girmaw Abebe Tadesse, Deogratias Mzurikwao, Rob Beyer, Darlington Akogo, Eva Weicken, Tafadzwa Matika, MaryJane Ijeoma Nweje, Watu Wamae, Sako Arts, Thomas Wiegand, Colin Bennett, Maha R Farhat, Matthias I Gröschel. “Rethinking global digital health and AI-for-health innovation challenges.” PLOS Glob Public Health 2023.
• Jana Fehr, Giovanna Jaramillo-Gutierrez, Luis Oala, Matthias I Gröschel, Manuel Bierwirth, Pradeep Balachandran, Alixandro Werneck-Leite, Christoph Lippert. “Piloting a Survey-Based Assessment of Transparency and Trustworthiness with Three Medical AI Tools.” Healthcare (Basel) 2022.

Childhood tuberculosis and public health

• Lasith Ranasinghe, Jay Achar, Matthias I Gröschel, Peter J Dodd, James A Seddon. “Global impact of COVID-19 on childhood tuberculosis: an analysis of notification data.” Lancet Global Health 2022.
• Matthias I Gröschel, James A Seddon, Satria A Prabowo, Giovanni B Migliori, Stephen M Graham, Martin van den Boom, Masoud Dara. “European guidance on drug-resistant tuberculosis in children and adolescents.” Lancet Child & Adolescent Health 2020.
• “Multidrug-resistant tuberculosis in children and adolescents in the WHO European Region - Expert Opinion.” Copenhagen: WHO Regional Office for Europe 2019. Lead author and coordinator of core writing group
• Matthias I Gröschel, Martin van den Boom, Giovanni B Migliori, Masoud Dara. “Prioritising children and adolescents in the tuberculosis response of the WHO European Region.” European Respiratory Review 2019.

Mycobacterial ESX secretion and tuberculosis vaccines

• Matthias I Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, MIckael Orgeur, Robin Canetti, Nadine Honore, Roxane Simeone, Tjip S van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch. “Recombinant BCG expressing ESX-1 of Mycobacterium marinum combines low virulence with cytosolic immune signaling and improved TB protection” Cell Reports 2017.
• Matthias I Gröschel, Fadel Sayes, Roxane Simeone, Laleh Majlessi, Roland Brosch. “ESX secretion systems: mycobacterial evolution to counter host immunity” Nature Reviews Microbiology 2016.
• Matthias I Gröschel, Satria A Prabowo, Pere-Joan Cardona, John L Stanford, Tjip S van der Werf. “Therapeutic vaccines for tuberculosis - a systematic review Vaccine 2014.

A complete list of publications is available at Google Scholar

I enjoy reading and share here the books I have read in the past years (random order).

• Juli Zeh. Über Menschen
• Carl Zimmer. Life's Edge: The Search for What It Means to Be Alive
• Robert Kolker. Hidden Valley Road: Inside the Mind of an American Family
• Euan Angus Ashley. The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them
• Paul Farmer. Fevers, Feuds, and Diamonds: Ebola and the Ravages of History
• Jeremy Howards & Sylain Gugger. Deep Learning for Coders with fastai & PyTorch.
• Edward O. Wilson. Letters to a Young Scientist.
• Gina Kolata. The Great Influenza: The Story of the Deadliest Pandemic in History.
• Vinay Prasad. Malignant: How Bad Policy and Bad Evidence Harm People with Cancer.
• Anand Giridharadas. Winners Take All: The Elite Charade of Changing the World.
• Marty Makary. The Price We Pay. What Broke American Health Care - And How To Fix It.
• Steven Pinker. Enlightenment Now: The Case for Reason, Science, Humanism, and Progress.
• Pedro Domingos. The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World.
• Yuval Noah Harari. Sapiens: A Brief History of Humankind.
• Atul Gawande. Being Mortal: Medicine and What Matters in the End.
• Ed Cohen. A Body Worth Defending: Immunity, Biopolitics, and the Apotheosis of the Modern Body.